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Piperlongumine (PL), an oxidative stress inducer, inhibits ZIKV replication in various cells, including the human brain microvascular, Vero, and human umbilical vein endothelial cells 129

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Different conditions or external stimuli may lead cells to different death pathways, with single-type or mixed-type pathways dominating, although mixed-type cell death appears to be more common than single-type death due to the sharing of common regulatory factors and signaling molecules (75)

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